- Recommended name
- Pinnatoxin H
- Synonyms
- Pinnatoxin-H
- Recommended acronym
- PnTX-H
- Abbreviation
Progenitors
- Name
- Vulcanodinium rugosum
- Note
- Selwood, A.I., Wilkins, A.L., Munday, R., Gu, H., Smith, K.F., Rhodes, L.L., Rise, F., 2014. Pinnatoxin H: a new pinnatoxin analogue from a South China Sea Vulcanodinium rugosum isolate. Tetrahedron Lett. 55(40), 5508-5510.
Vector Species
No vector species registered
References
- Selwood et al., 2014
- Selwood, A.I., Wilkins, A.L., Munday, R., Gu, H., Smith, K.F., Rhodes, L.L., Rise, F., 2014. Pinnatoxin H: a new pinnatoxin analogue from a South China Sea Vulcanodinium rugosum isolate. Tetrahedron Lett. 55(40), 5508-5510.
- Nézan & Chomérat, 2011
- Nézan, E., Chomérat, N., 2011. Vulcanodinium rugosum gen. et sp. nov. (Dinophyceae), un nouveau dinoflagellé marin de la côte méditerraneenne française. Cryptogamie, Algologie 32(1), 3-18.
- Structure
-
- Formula
- C43H65NO7
- Exact mono-isotopic mass
- 707.4761
- Molfile
- see chemfiles
- Alternative molfiles
- n/a
- SMILES
- C[C@@H](CN=C1CCCC(C[C@@H]2CC[C@](O)(C)[C@](O2)(O3)CC[C@@]3(O4)C[C@H](C)[C@H](O)[C@@H]4C5)=C)[C@@H](C)C[C@@]61[C@]([C@@H]7O[C@]85C[C@@H](C)C[C@H]7O8)([H])C=C(C=C)CC6
- Alternative SMILES
- n/a
- InChi key
- LDTRLBDECCUBLW-UEZLYXATSA-N
- Alternative InChi keys
- n/a
- InChi
- InChI=1S/C43H65NO7/c1-8-31-12-15-40-22-28(4)30(6)25-44-36(40)11-9-10-26(2)18-32-13-14-39(7,46)43(47-32)17-16-41(51-43)23-29(5)37(45)35(49-41)24-42-21-27(3)19-34(48-42)38(50-42)33(40)20-31/h8,20,27-30,32-35,37-38,45-46H,1-2,9-19,21-25H2,3-7H3/t27-,28-,29-,30-,32-,33+,34+,35-,37-,38-,39+,40+,41-,42-,43+/m0/s1
- Alternative InChis
- Spectra available
- True
- Chem files
- chemfiles/PnTX-H.cdxml chemfiles/PnTX-H.mol
- Certified
- False
- Certified links
-
-
n/a
- Non certified reference material
- Unknown
Chemical analysis
- Research
- True
- Standardized
- Unknown
- Validated
- Unknown
- Official
- n/a
Structure recognition assays
- Research
- Unknown
- Standardized
- Unknown
- Validated
- Unknown
- Official
- n/a
Functional assays
- Research
- True
- Standardized
- Unknown
- Validated
- Unknown
- Official
- n/a
Animal assays
- Research
- True
- Standardized
- Unknown
- Validated
- Unknown
- Official
- n/a
- Regulatory status
- False
- Human toxic syndrome(s)
- n/a
- Organ system toxicity
- n/a
- Risk assessment
- Unknown
- Molecular targets known
- Unknown
- Molecular targets
- Nicotinic acetylcholine receptors
- Toxic to aquatic animals
- Unknown
- TEF available
- False
- Notes
- Pinnatoxin H was first described by Selwood et al., 2014, from an isolate of Vulcanodinium rugosum originating from the South China Sea (Haifeng Gu). It has not been much reported further in the literature until a recent report of Vulcanodinium rugosum affecting fishermen in Senegal, although the effects were shown to be related to portimine A, rather than pinnatoxin H (Gorse et al., 2025)
References
- Selwood et al., 2014
- Selwood, A.I., Wilkins, A.L., Munday, R., Gu, H., Smith, K.F., Rhodes, L.L., Rise, F., 2014. Pinnatoxin H: a new pinnatoxin analogue from a South China Sea Vulcanodinium rugosum isolate. Tetrahedron Lett. 55(40), 5508-5510.
- Gorse et al., 2025
- Gorse, L., Plessis, L., Wearne, S., Paradis, M., Pinilla, M., Chua, R., Lim, S.S., Pelluz, E., TOH, G.-A., Mazars, R., Bomfim, C., Hervé, F., Lhaute, K., Réveillon, D., Suire, B., Ravon-Katossky, L., Benoist, T., Fromont, L., Péricat, D., Neil Mertens, K., Derrien, A., Terre-Terrillon, A., Chomérat, N., Bilien, G., Séchet, V., Carpentier, L., Fall, M., Sonko, A., Hakim, H., Sadio, N., Bourdeaux, J., Cougoule, C., Henras, A.K., Perez-Oliva, A.B., Brehmer, P., Roca, F.J., Zhong, F.L., Common, J., Meunier, E., Hess, P., 2025. Portimine A toxin causes skin inflammation through ZAKα-dependent NLRP1 inflammasome activation. EMBO Molecular Medicine 17(3), 535-562.